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Transcriptional Levels of PRUNE-1 are Correlated to Prognostic Parameters in Epithelial Tumors

Prognostic Parameters in Epithelial Tumors

The human orthologue of Drosophila PRUNE protein (PRUNE-1) regulates cell motility through its phosphodiesterase activity and interaction with protein partners, acting as a negative regulator of Nm23-H1, a tumor suppressor protein. Here, we aimed to understand the molecular alterations in epithelial tumors through quantification of PRUNE-1 transcriptional levels in patients with Prostate Cancer (PCa) and Breast Cancer (BC).

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